A Variability-Generating Circuit Goes Awry in a Songbird Model of the FOXP2 Speech Disorder
نویسندگان
چکیده
FOXP2 mutations cause a monogenic speech disorder in humans. In this issue of Neuron, Murugan et al. (2013) show that knockdown of FoxP2 in the songbird basal ganglia causes abnormal vocal variability and excess bursting in a frontal cortical nucleus.
منابع مشابه
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.
Humans and songbirds are two of the rare animal groups that modify their innate vocalizations. The identification of FOXP2 as the monogenetic locus of a human speech disorder exhibited by members of the family referred to as KE enables the first examination of whether molecular mechanisms for vocal learning are shared between humans and songbirds. Here, in situ hybridization analyses for FoxP1 ...
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Humans with mutations in the transcription factor FOXP2 display a severe speech disorder. Songbirds are a powerful model system to study FoxP2. Like humans, songbirds communicate via vocalizations that are imitatively learned during critical periods and this learning is influenced by social factors and relies on functionally lateralized neural circuits. During the past five years significant pr...
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عنوان ژورنال:
- Neuron
دوره 80 شماره
صفحات -
تاریخ انتشار 2013